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Dokumente

SML0238

Sigma-Aldrich

WEB2086

≥98% (HPLC)

Synonym(e):

3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone, Apafant, WEB 2086BS

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About This Item

Empirische Formel (Hill-System):
C22H22ClN5O2S
CAS-Nummer:
105219-56-5
Molekulargewicht:
455.96
MDL-Nummer:
MFCD00865271
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825250
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

DMSO: 10 mg/mL (clear solution)

Lagertemp.

2-8°C

SMILES String

Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4-n12

InChI

1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3

InChIKey

JGPJQFOROWSRRS-UHFFFAOYSA-N

Biochem./physiol. Wirkung

WEB 2086 inhibits PAF mediated chemotaxis and leukotriene C4 production in eosinophils. It prevents surge in airway resistance and cardiovascular side effects mediated by PAF inhalation.
WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist (IC50 = 16 nM). WEB2086 inhibits the proliferation of tumor cells and slows tumor growth in xenograft tumor models, and has been shown to inhibit angiogenesis.

Leistungsmerkmale und Vorteile

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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C Cellai et al.
British journal of cancer, 94(11), 1637-1642 (2006-05-25)
WEB-2086 -- an antagonist of platelet-activating factor receptor (PAFR) with known anti-inflammatory, antiangiogenic and antileukaemic properties -- also proved to inhibit the proliferation in human solid tumour cell lines of different histology, and with much higher efficacy than in normal
Eduardo Tibiriçá et al.
Journal of ethnopharmacology, 111(1), 50-55 (2006-12-08)
We investigated the vascular effects of a crude aqueous extract (AEEG) of Echinodorus grandiflorus (Alismataceae) using the in vitro experimental models of the rabbit isolated aorta and perfused kidney. Echinodorus grandiflorus, a native semi-aquatic plant widely distributed in Brazil, has
Valérie Declerck et al.
The Journal of organic chemistry, 74(5), 2004-2007 (2009-02-10)
The 1,3-dipolar cycloaddition of linear azido alkynes derived from protected beta-amino esters proceeds via diastereomeric differentiation to provide trans-disubstituted triazolodiazepines in good yields.
A Laurenzana et al.
Leukemia, 19(3), 390-395 (2005-01-28)
PAF-receptor antagonists WEB-2086 and WEB-2170 (WEBs) have been previously shown to induce differentiation in murine and human leukemia cells. The present study describes the apoptotic-differentiative effect of WEBs in all-trans-retinoic acid (ATRA)-sensitive (NB4) and -resistant (NB4-007-6 and NB4-MR4) acute promyelocytic
Evandro M M Machado et al.
Journal of insect physiology, 52(7), 685-692 (2006-06-17)
The effects of the triazolodiazepine WEB 2086, a platelet-activating factor (PAF) antagonist, on hemocyte microaggregation and prophenoloxidase (proPO)-activating system in the hemolymph, hemocoelic infection and mortality in fifth-instar larvae of Rhodnius prolixus inoculated with Trypanosoma rangeli were investigated. Hemocoelic injection
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