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SML0235

Sigma-Aldrich

CDPPB

≥98% (HPLC)

Synonym(e):

3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide

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About This Item

Empirische Formel (Hill-System):
C23H16N4O
CAS-Nummer:
781652-57-1
Molekulargewicht:
364.40
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825248
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: ≥5 mg/mL at warmed to 60 °C

Lagertemp.

2-8°C

SMILES String

O.O=C(Nc1cc(nn1-c2ccccc2)-c3ccccc3)c4cccc(c4)C#N

InChI

1S/C23H16N4O.H2O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20;/h1-15H,(H,25,28);1H2

InChIKey

GZHZEGYXLNXEBV-UHFFFAOYSA-N

Anwendung

CDPPB may be used in mGluR5-mediated cell signaling studies.

Biochem./physiol. Wirkung

Activation of metabotropic glutamate 5 receptor by CDPPB enhances the function of NMDA receptor and markers of neuronal plasticity. This improves recognition memory and cognition deficits in schizophrenia.
CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
122M4611V
012M4607V

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In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experiments indicate that mGluR5 positive allosteric
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