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SML0039

Sigma-Aldrich

Armodafinil

≥98% (HPLC)

Synonym(e):

(R)-Modafinil; 2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide, CEP 10952, CRL 40982, Nuvigil

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About This Item

Empirische Formel (Hill-System):
C15H15NO2S
CAS-Nummer:
112111-43-0
Molekulargewicht:
273.35
MDL-Nummer:
MFCD09841055
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825109
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Optische Aktivität

[α]/D -15 to -20° in methanol (C=1)

Farbe

white to tan

Löslichkeit

DMSO: ≥16 mg/mL

Ersteller

Teva

Lagertemp.

2-8°C

SMILES String

NC(=O)CS(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1

InChIKey

YFGHCGITMMYXAQ-LJQANCHMSA-N

Angaben zum Gen

human ... SLC6A3(6531)

Anwendung

Armodafinil may be used in cell signaling studies.

Biochem./physiol. Wirkung

Armodafinil has affinity for dopamine transporters and inhibits the uptake of dopamine in brain areas that are involved in the cognitive performances. It is beneficial for the patients of substance abuse and mental disorders.
Armodafinil is a non-amphetamine, having a half-life of 10−14 hours.
Armodafinil is the R isomer and longer-lasting isomer of racemic modafinil. It is a psychostimulant wake-promoting agent developed for the treatment of narcolepsy, shift work sleep disorder and excessive daytime sleepiness associated with obstructive sleep apnea

Leistungsmerkmale und Vorteile

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation markHealth hazard
GHS07,GHS08

Signalwort

Warning

H-Sätze

H302 - H361d

Gefahreneinstufungen

Acute Tox. 4 Oral - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Marianna Harvanová et al.
Journal of pharmaceutical and biomedical analysis, 138, 267-271 (2017-02-24)
For the first time, a new, fast and sensitive chromatographic method for the separation and determination of modafinil enantiomers was developed on chiral stationary phase with macrocyclic glycopeptide teicoplanin in the polar organic mode. The effect of the mobile phase
Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives
Darwish M, et al.
Clinical Drug Investigation, 29(9), 613-623 (2009)
Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome
Hirshkowitz M, et al.
Respiratory Medicine, 101(3), 616-627 (2007)
Maddalena Mereu et al.
Psychopharmacology, 229(3), 415-434 (2013-08-13)
Modafinil (MOD) and its R-enantiomer (R-MOD) are approved medications for narcolepsy and other sleep disorders. They have also been used, off-label, as cognitive enhancers in populations of patients with mental disorders, including substance abusers that demonstrate impaired cognitive function. A

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