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Merck

SBR00068

Sigma-Aldrich

Streptomycin Ready Made Solution

100 mg/mL in water

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About This Item

CAS-Nummer:
UNSPSC-Code:
51281624
NACRES:
NA.76

Form

liquid

Qualitätsniveau

Spezifische Aktivität

(Antibacterial)

Konzentration

100 mg/mL in water

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Wirkungsweise

protein synthesis | interferes

Lagertemp.

−20°C

Allgemeine Beschreibung

Chemical structure: aminoglycoside

Anwendung

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50 μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Biochem./physiol. Wirkung

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Lagerung und Haltbarkeit

  • Streptomycin ready made solution contains 100 mg/mL streptomycin sulfate in water.
  • Streptomycin: sulfate salt ratio is 1:1.5.
  • The product is packed under aseptic conditions.

Piktogramme

Health hazard

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Repr. 2

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3


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