SAB5702238

Anti-PD-L1/CD274 Antibody, clone 8F1V6, Rabbit Monoclonal

• Synonym(e): B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1,CD274
• UNSPSC-Code: 12352203
• NACRES: NA.46

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Materialien: colorless
• Klon: 8F1V6, monoclonal
• Form: liquid
• Speziesreaktivität: human
• Konzentration: 0.65 mg/mL
• Methode(n): flow cytometry: 1:50 - 1:200
• Farbe: colorless
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: Q9NZQ7
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PD-L1(29126)

Beschreibung

Allgemeine Beschreibung

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

Immunogen

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human PD-L1/CD274.

Anwendung

ELISA, WB, FC, Inhibition

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1