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Key Documents

SAB4500545

Sigma-Aldrich

Anti-Catenin-β antibody produced in rabbit

affinity isolated antibody

Synonym(e):

CATNB, CTNB1, CTNNB, catenin β, catenin (cadherin-associated protein) β 1

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About This Item

MDL-Nummer:
MFCD00282178
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 85 kDa

Speziesreaktivität

rat, mouse, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

P35222

UniProt-Hinterlegungsnummer

P35222

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CTNNB1(1499)

Allgemeine Beschreibung

Anti-Catenin-β Antibody detects endogenous levels of total Catenin-β protein.
Catenin-β is a multifunctional protein, coded by CTNNB1 (catenin β 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Catenin-beta.

Immunogen Range: 455-504

Biochem./physiol. Wirkung

Mutations in β-Catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing to BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. It plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

?-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
Geyer FC, et al.
Modern Pathology, 24(2), 209-231 (2011)
Combined inhibition of ?-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo
Zhou H, et al.
Leukemia, 31(10), 2065-2074 (2017)
Defects in the Cell Signaling Mediator ?-Catenin Cause the Retinal Vascular Condition FEVR
Panagiotou ES, et al.
American Journal of Human Genetics, 100(6), 960-968 (2017)
Jessica Neville Little et al.
Human molecular genetics, 28(3), 434-447 (2018-10-12)
Building a cerebral cortex of the proper size involves balancing rates and timing of neural stem cell (NSC) proliferation, neurogenesis and cell death. The cellular mechanisms connecting genetic mutations to brain malformation phenotypes are still poorly understood. Microcephaly may result

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