Direkt zum Inhalt
Merck

SAB4301526

Sigma-Aldrich

Anti-phospho-mTOR (pSer2481) antibody produced in rabbit

affinity isolated antibody

Synonym(e):

FRAP, FRAP1, FRAP2, RAFT1, RAPT1

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

288 kDa

Speziesreaktivität

rat, human, mouse

Konzentration

1.0 mg/mL

Methode(n)

western blot: 1:500-1:1000 (Cell Lysate)

Isotyp

IgG

Hinterlegungsnummer

NP_004949.1 

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pSer2481)

Angaben zum Gen

human ... MTOR(2475)

Allgemeine Beschreibung

Mechanistic target of rapamycin kinase (MTOR) is a serine/threonine kinase. mTOR belongs to the family of phosphatidylinositol kinase-related kinase (PIKK). mTOR exists as two different complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). In human chromosome, the gene MTOR is localized on 1p36.22.

Spezifität

The antibody detects endogenous level of mTOR only when phosphorylated at Serine 2481.

Immunogen

Peptide sequence around phosphorylation site of Serine 2481(I-H-S(p)-F-I) derived from Human mTOR.

Anwendung

Anti-phospho-mTOR (pSer2481) antibody produced in rabbit has been used in western blot analysis.

Biochem./physiol. Wirkung

Mechanistic target of rapamycin kinase (MTOR) recognizes various intracellular and extracellular signals and processes them to regulate cell growth, metabolism, proliferation and survival. mTOR is also involved in mitochondrial respiration by activating oxidative phosphorylation. Deregulation of mTOR phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) complex signalling pathway, leads to leukaemogenesis. Mutations leading to aberrant expression of mTOR causes cancer cachexia. mTOR plays a key role in synaptic plasticity and autophagy. Polymorphism of mTOR is associated with brain malformation and various neuropsychiatric disorders like brain ischemia, autism, epilepsy, schizophrenia etc. mTOR is a key regulator of anabolic and catabolic processes. mTOR is activated by insulin or insulin like growth factor 1 (IGF1) and regulate PI3K/Akt/mTOR/tuberous sclerosis (TSC)/the small GTPase (guanidine triphosphatase) Ras (rat sarcoma) homologue enriched in brain (RHEB) signalling pathway. mTOR is a key regulator of lipid biogenesis by influencing lipogenic genes like sterol regulatory element-binding protein 1 (SREBP1). Dysregulation of mTOR is associated with type 2 diabetes and obesity.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

mTOR and Tumor Cachexia
Duval AP, et al.
International Journal of Molecular Sciences, 19(8), 2225-2225 (2018)
mTOR-related brain dysfunctions in neuropsychiatric disorders
Ryskalin L, et al.
International Journal of Molecular Sciences, 19(8), 2226-2226 (2018)
Role of mTOR in Glucose and Lipid Metabolism
Mao Z and Zhang W
International Journal of Molecular Sciences, 19(7), 2043-2043 (2018)
Comparative integromics on Angiopoietin family members
Katoh Y and Katoh M
International Journal of Molecular Sciences, 17(6), 1145-1149 (2006)
Biological Aspects of mTOR in Leukemia
Mirabilii S, et al.
International Journal of Molecular Sciences, 19(8), 2396-2396 (2018)

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.