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SAB4200768
Anti-Human IgG1-Peroxidase antibody, Mouse monoclonal
clone 8c/6-39, purified from hybridoma cell culture
Synonym(e):
Anti-Human immunoglobulin G1
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.46
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Konjugat
peroxidase conjugate
Antikörperform
purified from hybridoma cell culture
Antikörper-Produkttyp
primary antibodies
Klon
8c/6-39, monoclonal
Form
lyophilized
Speziesreaktivität
human
Konzentration
~2 mg/mL
Methode(n)
ELISA: 1:8,000-1:16,000 using 5 μg/ml human IgG1 for coating
Isotyp
IgG2a
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Allgemeine Beschreibung
Human IgGs consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5, and 4% of the total IgG, respectively. Each subclass has different biological and physiochemical properties.Monoclonal Anti-Human IgG1 specifically recognizes Human IgG1. The antibody shows no cross-reactivity with human IgG2, IgG3, or IgG4. This clone has been established as a useful human IgG1 specificity standard by the WHO/IUIS.
Monoclonal Anti-Human IgG1 (mouse IgG2a isotype) is derived from the 8c/6-39 hybridoma (also known as HP6019), produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with the Fc fragment of a human IgG1 myeloma protein.
Immunogen
The Fc fragment of a human IgG1 myeloma protein
Anwendung
The antibody is recommended to use in various immunological techniques, including ELISA.
Biochem./physiol. Wirkung
The immunoglobin G (IgG) subclass may be preferentially produced in response to different antigens and pathological conditions. For instance, anti-polysaccharide responses are mainly of the IgG2 subclass while protein antigens give rise to IgG1 and IgG3 antibodies. Human IgG1 is the main antibody produced against tetanus toxoid antibodies. Elevation of IgG1 levels has been found in the cerebral spinal fluid of patients with multiple sclerosis.
Physikalische Form
Supplied as lyophilized powder. After reconstitution with 0.1 mL of distilled water to a final antibody concentration of ∼ 2 mg/mL, the solution contains 1% BSA, 2.5% trehalose, 0.05% MIT in 0.01 M sodium phosphate buffered saline
Sonstige Hinweise
This product is for R&D use only, not for drug, household, or other uses.
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Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Skin Sens. 1
Lagerklassenschlüssel
13 - Non Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Cerebrospinal fluid total tau protein levels in patients with multiple sclerosis
Terzi M, et al.
Acta Neurologica Scandinavica, 115(5), 325-330 (2007)
B Rocchelli et al.
European neurology, 22(1), 35-42 (1983-01-01)
The IgG oligoclonal bands in CSF can be found in high percentage of MS patients but the existence of a limited number of cases with CSF normal IgG profile is known as well. In the present study 63 out of
R Jefferis et al.
Annales de biologie clinique, 52(1), 57-65 (1994-01-01)
Secondary systemic immune responses are predominantly of the IgG class and passive administration of intravenous IgG, from pooled normal serum, is an effective prophylactic and/or therapeutic treatment for patients with defined immunodeficiencies. However, the proportions of each IgG subclass present
R Stevens et al.
Journal of clinical immunology, 3(1), 65-69 (1983-01-01)
Peripheral blood leukocytes from individuals immunized with tetanus toxoid can be stimulated by pokeweed mitogen to produce IgG anti-tetanus toxoid antibody (IgG-Tet) in vitro. Previous studies have shown that treatment of these cells with tetanus toxoid or anti-human IgG reagents
F W van der Meulen et al.
British journal of haematology, 46(1), 47-56 (1980-09-01)
The purpose of this study was to determine whether quantitative or qualitative factors are of major importance in the destruction of red cells sensitized with incomplete warm autoantibodies of subclass IgG1. To that end, the relative amount of igG1 antibody
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