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Merck

SAB3700041

Sigma-Aldrich

Anti-Bovine IgM (μ-chain specific) antibody produced in rabbit

whole antiserum, lyophilized powder

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.46

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

whole antiserum

Antikörper-Produkttyp

secondary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

bovine

Methode(n)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Versandbedingung

wet ice

Lagertemp.

2-8°C

Posttranslationale Modifikation Target

unmodified

Allgemeine Beschreibung

During the B-cell development, IgM (immunoglobulin M) is the first expressed antibody. It is present as a monomer on the surface of naive B cells. Antigenic stimulation and upon maturation, the monomeric IgM units (190kDa), are linked by disulfide bonds to form a pentameric immunoglobulin structure. It also but rarely forms a hexameric structure. The pentameric IgM is linked by a disulfide bond, a polypeptide chain and a J-chain. The μ -chain consists of five domains- VH, Cμ1, Cμ2, Cμ3 and Cμ4.

Spezifität

This product was prepared from monospecific antiserum by a delipidation and defibrination. Assay by immunoelectrophoresis resulted in a single precipitin arc against Bovine IgM and Bovine Serum. No reaction was observed against Bovine IgG F(ab′)2 or Bovine IgG F(c).

Immunogen

Bovine IgM mu heavy chain

Biochem./physiol. Wirkung

The J-chain of the multimeric IgM (immunoglobulin M) structure is responsible for secretion at the mucosal surfaces. The pentameric form of IgM, has a greater affinity towards antigens (with multiple repeating epitopes) compared to the monomers. IgM pentamer enables better opsonization of antigens for destruction and fixing complement.

Physikalische Eigenschaften

Antibody format: Antiserum

Physikalische Form

Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Rekonstituierung

Reconstitute with 1.0 mL deionized water (or equivalent).

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Immunobiology: The Immune System in Health and Disease (2005)
Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
Kun Song
PLoS ONE, 9(2), e88701-e88701 (2014)
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)

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