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Merck

SAB2108447

Sigma-Aldrich

Anti-BAX

IgG fraction of antiserum

Synonym(e):

Anti-CLECSF10

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

21 kDa

Speziesreaktivität

bovine, human, dog, pig

Konzentration

0.5-1 mg/mL

Methode(n)

immunoblotting: suitable
immunohistochemistry: suitable

Hinterlegungsnummer

NM_138761

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... BAX(581)

Allgemeine Beschreibung

B-cell lymphoma 2 associated X (BAX), also known as CLECSF10 (C-type lectin superfamily member 10), is located on human chromosome 19q13. BAX is a proapoptotic protein and is a member of Bcl-2 protein family.

Immunogen

Synthetic peptide directed towards the N terminal region of human BAX

Anwendung

Anti-BAX has been used in Western blotting.

Biochem./physiol. Wirkung

B-cell lymphoma 2 associated X (BAX) promotes cell death and plays a vital role in regulation of apoptosis. BAX gene may act as a negative regulator of autophagy in CRC (colorectal cancer) development.

Sequenz

Synthetic peptide located within the following region: MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPV

Physikalische Form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Enhanced radiation effect on SMCC7721 cells through endoplasmic reticulum stress induced by C225-GNPs in vitro and in vivo
Zhu C, et al.
Oncology Letters, 15, 4221-4228 (2018)
Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
Luciano F, et al.
The Journal of Biological Chemistry, 280, 15825-15835 (2005)
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.
Selvakumaran M, et al.
Oncogene, 9, 1791-1798 (1994)
The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer
Gil J, et al.
Medical Oncology (Northwood, London, England), 34 (2017)
The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria.
Simonyan L, et al.
Biochimica et Biophysica Acta, 1859, 1144-1155 (2017)

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