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S9446

Sigma-Aldrich

Sphingosine Kinase 1 human

aqueous glycerol solution

Synonym(e):

SPHK 2

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About This Item

EC-Nummer:
2.7.1.91 (BRENDA, IUBMB)
MDL-Nummer:
MFCD09265456
UNSPSC-Code:
12352204
NACRES:
NA.54

Rekombinant

expressed in baculovirus infected insect cells

Qualitätsniveau

200

Form

solution

Spezifische Aktivität

≥10 units/μg

Mol-Gew.

47 kDa

UniProt-Hinterlegungsnummer

Q9NYA1

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... SPHK1(8877)

Allgemeine Beschreibung

Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.

Anwendung

Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia.

Biochem./physiol. Wirkung

Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei.

Einheitendefinition

One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 °C.

Physikalische Form

Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT.
aqueous glycerol solution

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Mark E Schnute et al.
The Biochemical journal, 444(1), 79-88 (2012-03-09)
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhibition of S1P signalling has been
Zhengshan Zhao et al.
The Journal of biological chemistry, 287(8), 5562-5573 (2011-12-24)
Loss of insulin-producing β-cell mass is a hallmark of type 2 diabetes in humans and diabetic db/db mice. Pancreatic β-cells can modulate their mass in response to a variety of physiological and pathophysiological cues. There are currently few effective therapeutic
Keith S Mascall et al.
Journal of cell science, 125(Pt 9), 2267-2275 (2012-02-22)
Following myocardial infarction, angiogenesis occurs as a result of thrombus formation, which permits reperfusion of damaged myocardium. Sphingosine 1-phosphate (S1P) is a naturally occurring lipid mediator released from platelets and is found in high concentrations at sites of thrombosis. S1P

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