S7826

SMER3

≥98% (HPLC)

• Synonym(e): 9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one
• Empirische Formel (Hill-System): C₁₁H₄N₄O₂
• CAS-Nummer: 67200-34-4
• Molekulargewicht: 224.18
• MDL-Nummer: MFCD00451458
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824591
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: DMSO: ≥30 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O=C1c2ccccc2-c3nc4nonc4nc13
• InChI: 1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
• InChIKey: SFSSAKVWCKFRHE-UHFFFAOYSA-N

Beschreibung

Anwendung

SMER3 may be used in cell signaling studies.

Biochem./physiol. Wirkung

Inhibition of SCF^Met30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.¹

Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable