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S5576

Sigma-Aldrich

SKA-31

≥98% (HPLC)

Synonym(e):

Naphtho[1,2-d]thiazol-2-ylamine

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About This Item

Empirische Formel (Hill-System):
C11H8N2S
CAS-Nummer:
40172-65-4
Molekulargewicht:
200.26
MDL-Nummer:
MFCD00051329
UNSPSC-Code:
12352202
PubChem Substanz-ID:
329824457
NACRES:
NA.25

Assay

≥98% (HPLC)

Form

solid

Löslichkeit

DMSO: ≥30 mg/mL

Lagertemp.

−20°C

SMILES String

Nc1nc2c(ccc3ccccc23)s1

InChI

1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)

InChIKey

FECQXVPRUCCUIL-UHFFFAOYSA-N

Biochem./physiol. Wirkung

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H319

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Alexander I Bondarenko et al.
Vascular pharmacology, 89, 39-48 (2017-01-09)
Lysophosphatidylinositol (LPI) and lysophosphatidylcholine (LPC) are lipid signaling molecules that induce endothelium-dependent vasodilation. In addition, LPC suppresses acetylcholine (Ach)-induced responses. We aimed to determine the influence of LPC and LPI on hyperpolarizing responses in vitro and in situ endothelial cells
Giuseppina D'Alessandro et al.
Cancers, 11(3) (2019-03-01)
Glioblastoma (GBM) is a deadly brain tumor, with fast recurrence even after surgical intervention, radio- and chemotherapies. One of the reasons for relapse is the early invasion of surrounding brain parenchyma by GBM, rendering tumor eradication difficult. Recent studies demonstrate
Md A Hakim et al.
Journal of Alzheimer's disease : JAD, 76(4), 1423-1442 (2020-07-12)
Development of Alzheimer's disease (AD) pathology is associated with impaired blood flow delivery of oxygen and nutrients throughout the brain. Cerebrovascular endothelium regulates vasoreactivity of blood vessel networks for optimal cerebral blood flow. We tested the hypothesis that cerebrovascular endothelial
Sulie L Chang et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2018-07-11)
Ethanol (EtOH), the main ingredient in alcoholic beverages, is well known for its behavioral, physiological, and immunosuppressive effects. There is evidence that EtOH acts through protein targets to exert its physiological effects; however, the mechanisms underlying EtOH's effects on inflammatory
Monika Kloza et al.
International journal of molecular sciences, 20(17) (2019-08-28)
The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance calcium-activated potassium channels, and to evaluate its influence on endothelium-derived hyperpolarization (EDH)-KCa2.3/KCa3.1 type relaxation in isolated endothelium-intact
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