C2901

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated

≥95% (HPLC), powder

• Synonym(e): CCK-8, non-sulfated
• Empirische Formel (Hill-System): C₄₉H₆₂N₁₀O₁₃S₂
• CAS-Nummer: 25679-24-7
• Molekulargewicht: 1063.21
• MDL-Nummer: MFCD00076488
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24892546
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥95% (HPLC)
• Form: powder
• UniProt-Hinterlegungsnummer: P06307
• Lagertemp.: −20°C
• SMILES String: CSCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(Cc4ccccc4)C(N)=O
• InChI: 1S/C49H62N10O13S2/c1-73-18-16-34(55-47(70)37(21-28-12-14-30(60)15-13-28)58-44(67)32(50)23-41(62)63)45(68)53-26-40(61)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(71)56-35(17-19-74-2)46(69)59-39(24-42(64)65)49(72)57-36(43(51)66)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52,60H,16-24,26,50H2,1-2H3,(H2,51,66)(H,53,68)(H,54,61)(H,55,70)(H,56,71)(H,57,72)(H,58,67)(H,59,69)(H,62,63)(H,64,65)
• InChIKey: OIXQINQYMGNCII-UHFFFAOYSA-N
• Angaben zum Gen: human ... CCK(885)

Beschreibung

Amino Acid Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2

Anwendung

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated has been used in the specificity testing against gastrin and pepsinogen I proteins.

Biochem./physiol. Wirkung

Biologically inactive form of CCK-8; CCK_B/gastrin receptor agonist that has no activity at the CCK_A receptor.

Cholecystokinin (CCK) is a 115 amino acid preprohormone and a neurotransmitter. It exists in many isoforms. The octapeptide of CCK (CCK-8S) is the most abundant form. CCK is mapped to human chromosome 3p22.1. CCK interacts with receptors of the gastrointestinal tract and nervous system. Polymorphisms in the CCK is implicated in hallucinations in patients with Parkinson′s disease. CCK plays a key role in the activation of the calcineurin-regulated nuclear factor of activated T-cells (NFATs).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)