S3134

Streptokinase aus beta;-haemolytischer Streptococcus (Lancefield Gruppe C)

lyophilized powder, ≥2,000 units/mg solid

• Synonym(e): Streptokinase from Streptococcus hemolyticus
• CAS-Nummer: 9002-01-1
• EC-Nummer: 3.4.99.0 (BRENDA, IUBMB)
• EG-Nummer: 232-647-1
• MDL-Nummer: MFCD00082037
• UNSPSC-Code: 12352204
• eCl@ss: 32160410
• NACRES: NA.54

Eigenschaften

• Form: lyophilized powder
• Spezifische Aktivität: ≥2,000 units/mg solid
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• InChI: 1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
• InChIKey: XRZWVSXEDRYQGC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

Anwendung

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

Biochem./physiol. Wirkung

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

Einheitendefinition

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

Physikalische Form

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable