S2071

Anti-Sodium Channel Na_V1.8 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-PN3, Anti-SCN10A
• MDL-Nummer: MFCD08705520
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: rat
• Methode(n): immunohistochemistry (frozen sections): suitable using adult rat DRG; western blot: 1:200 using rat DRG lysates
• UniProt-Hinterlegungsnummer: Q62968
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SCN10A(6336) ; mouse ... Scn10a(20264) ; rat ... Scn10a(29571)

Beschreibung

Allgemeine Beschreibung

Sodium voltage-gated channel α subunit 10 (SCN10A) codes for Nav1.8 sodium channels. It is expressed in nociceptive neurons. This gene is mapped to human chromosome 3p22.2.

Immunogen

peptide (C)EDEVAAKEGNSPGPQ corresponding to residues 1943-1957 of rat Na_v1.8. This sequence has 14/15 residues identical in mouse and 7/15 residues identical in human.

Anwendung

Anti-Sodium Channel NaV1.8 antibody has been used in immunohistochemistry and immunocytochemistry.

Biochem./physiol. Wirkung

Sodium voltage-gated channel α subunit 10 (SCN10A) plays a major role in human pain. It is involved in the pathophysiology of cerebellar deficits in MS (multiple sclerosis).

Zielbeschreibung

Anti-Sodium Channel Na_V1.8 specifically recognizes Na_V1.8. Voltage-gated sodium channels (VGSCs) are present in most excitable cells. They play a crucial role in regulating the cell excitability, being primarily responsible for the

Physikalische Form

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05 % sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable