S1438

Sulindac sulfone

≥94% (HPLC), (solid or powder)

• Synonym(e): (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid
• Empirische Formel (Hill-System): C₂₀H₁₇FO₄S
• CAS-Nummer: 59864-04-9
• Molekulargewicht: 372.41
• MDL-Nummer: MFCD01317811
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24278693
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥94% (HPLC)
• Form: (solid or powder)
• Farbe: , Light Yellow to Dark Yellow
• Löslichkeit: DMSO: >25 mg/mL; ethanol: 3 mg/mL (warm); acetone: 5 mg (plus 0.1 ml)
• Ersteller: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES String: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(C)(=O)=O
• InChI: 1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+
• InChIKey: MVGSNCBCUWPVDA-RQZCQDPDSA-N

Beschreibung

Anwendung

Human endothelial cells, HMEC-1 were treated with Sulindac sulfone and the effect on cell survival was studied by MTT assay.

Biochem./physiol. Wirkung

Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells^1,2 and reduces tumor burden in adenomatous polyposis patients.³

Metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. Inhibits the development and induces regression of premalignant adenomatous polyps.

Leistungsmerkmale und Vorteile

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Sulindac sulfone yields clear, light yellow to dark yellow solution in acetone at 50 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)