S143

(±)-6-Chloro-PB hydrobromide

≥98% (HPLC), solid

• Synonym(e): (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-81297 hydrobromide
• Empirische Formel (Hill-System): C₁₆H₁₆ClNO₂ · HBr
• CAS-Nummer: 71636-61-8
• Molekulargewicht: 370.67
• MDL-Nummer: MFCD00153782
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277934
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Farbe: white to light tan
• Löslichkeit: H₂O: 1.7 mg/mL; DMSO: >10 mg/mL; ethanol: 6.3 mg/mL
• SMILES String: Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3
• InChI: 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
• InChIKey: RMIJGBMRNYUZRG-UHFFFAOYSA-N
• Angaben zum Gen: human ... DRD1(1812)

Beschreibung

Anwendung

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

Biochem./physiol. Wirkung

(+/-)-6-Chloro-PB HBr is a full D₁ dopamine receptor agonist.

Vorsicht

Product is air and light sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves