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Merck

S1277

Sigma-Aldrich

Streptomycin -sulfat (Salz)

powder, BioXtra, suitable for mouse embryo cell culture

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About This Item

Lineare Formel:
C21H39N7O12 · 1.5 H2SO4
CAS-Nummer:
Molekulargewicht:
728.69
Beilstein:
3894995
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352207
PubChem Substanz-ID:
NACRES:
NA.75

Produktlinie

BioXtra

Qualitätsniveau

Form

powder

Wirksamkeit

≥720 I.U. per mg

Methode(n)

cell culture | embryo: suitable

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Wirkungsweise

protein synthesis | interferes

Lagertemp.

2-8°C

SMILES String

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

InChIKey

QTENRWWVYAAPBI-YZTFXSNBSA-N

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Allgemeine Beschreibung

Chemical structure: aminoglycoside

Anwendung

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Biochem./physiol. Wirkung

Wirkungsweise: Streptomycin wirkt durch die Hemmung der Prokaryoten-Proteinsynthese, indem es an das S12-Protein der 30S-Untereinheit des Ribosoms bindet und dadurch die Translation vom Initiationskomplex zum kettenverlängernden Ribosom verhindert. Dadurch entsteht eine Fehlcodierung bzw. die Initiation wird gehemmt.

Widerstandsmechanismus: Eine Mutation in rpsL, einem Gen für das ribosomale Protein S12, verhindert die Bindung von Streptomycin an das Ribosom. Durch eine Aminoglycosid-Phosphotransferase wird Streptomycin ebenfalls inaktiviert.

Antimikrobielles Spektrum: Streptomycin wirkt gegen gramnegative und grampositive Bakterien.

Vorsicht

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Angaben zur Herstellung

Stock solutions should be prepared with sterile water at concentrations between 20-25 mg/ml.

Piktogramme

Health hazardExclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Artikel

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome.

Protokolle

Extraction and quantitative analysis of aminoglycosides in porcine tissue, using molecular imprinted polymer solid phase extraction followed by LC-MS/MS.

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