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S1194

Sigma-Aldrich

SB-258585 dihydrochloride

≥98% (HPLC), powder

Synonym(e):

4-Iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide

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About This Item

Empirische Formel (Hill-System):
C18H22N3O3SI · 2HCl
Molekulargewicht:
560.28
MDL-Nummer:
MFCD06201856
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329824464
NACRES:
NA.77

Beschreibung

Store under nitrogen; package with desiccants at 4°C

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Ersteller

GlaxoSmithKline

Lagertemp.

2-8°C

SMILES String

Cl[H].Cl[H].COc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1N3CCN(C)CC3

InChI

1S/C18H22IN3O3S.2ClH/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16;;/h3-8,13,20H,9-12H2,1-2H3;2*1H

InChIKey

QDYGVTFRTVLFCD-UHFFFAOYSA-N

Biochem./physiol. Wirkung

5-HT6 serotonin receptor antagonist.

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

Gefahreneinstufungen

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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W D Hirst et al.
British journal of pharmacology, 130(7), 1597-1605 (2000-08-06)
SB-258585 (4-Iodo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzen esulphonamide) is a high affinity ligand at 5-HT(6) receptors. It displays over 100 fold selectivity for the 5-HT(6) receptor over all other 5-HT receptors tested so far. SB-258585 has been radiolabelled, to high specific activity, for its characterization
C Routledge et al.
British journal of pharmacology, 130(7), 1606-1612 (2000-08-06)
SB-271046, potently displaced [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT(6) receptors recombinantly expressed in HeLa cells in vitro (pK(i) 8.92 and 9.09 respectively). SB-271046 also displaced [(125)I]-SB-258585 from human caudate putamen and rat and pig striatum membranes (pK(i) 8.81, 9.02 and
Jennifer C Roberts et al.
Brain research, 934(1), 49-57 (2002-04-09)
We used the highly selective 5-HT(6) receptor radioligand [(125)I]SB-258585 (4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide) to perform autoradiographic binding studies on the rat brain. High levels of specific binding occurred in the corpus striatum, nucleus accumbens, Islands of Calleja and the olfactory tubercle. A high
Wei Zhang et al.
Scientific reports, 8(1), 15753-15753 (2018-10-27)
Epidemiological observations have shown that schizophrenia patients after long-term drug treatment exhibited reduced tumor incidences. The potential anticancer effects of antipsychotic drugs are subsequently demonstrated. These drugs are of great interest as agents against untreatable brain metastases because of their

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