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Merck

R7150

Sigma-Aldrich

Ro 25-6981 hydrochloride hydrate

≥98% (HPLC), powder

Synonym(e):

R)-(4-Hydroxyphenyl)-(βS)-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

Empirische Formel (Hill-System):
C22H29NO2 · HCl · xH2O
CAS-Nummer:
Molekulargewicht:
375.93 (anhydrous basis)
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white

Löslichkeit

DMSO: >20 mg/mL

Ersteller

Roche

SMILES String

O.Cl.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3

InChI

1S/C22H29NO2.ClH.H2O/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H;1H2/t17-,22+;;/m0../s1

InChIKey

FEINQVNMUYISNW-HVDCVHHPSA-N

Angaben zum Gen

human ... GRIN2B(2904)

Anwendung

Ro 25-6981 hydrochloride hydrate has been used:
  • as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
  • as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
  • to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus

Biochem./physiol. Wirkung

Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic-ischemic injury
Lai Q, et al.
Molecular Medicine Reports, 13(1), 206-212 (2016)
G Fischer et al.
The Journal of pharmacology and experimental therapeutics, 283(3), 1285-1292 (1998-02-12)
The interaction of Ro 25-6981 with N-methyl-D-aspartate (NMDA) receptors was characterized by a variety of different tests in vitro. Ro 25-6981 inhibited 3H-MK-801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0.003 microM and 149
Ya-Bing Zhu et al.
Journal of neuropathology and experimental neurology, 79(7), 800-808 (2020-05-10)
The mechanisms underlying type-2 diabetic neuropathic pain (DNP) are unclear. This study investigates the coupling of postsynaptic density-95 (PSD-95) to N-methyl-D-aspartate receptor subunit 2B (GluN2B), and the subsequent phosphorylation of GluN2B (Tyr1472-GluN2B) in the spinal cord in a rat model
NR2A-and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Gilmartin MR, et al.
Learning & Memory, 20(6), 290-294 (2013)
Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor
Ghersi MS, et al.
Psychopharmacology, 232(10), 1843-1857 (2015)

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