27840

Corticosteron

≥98.5% (HPLC)

• Synonym(e): 11β,21-Dihydroxy-4-pregnen-3,20-dion, 11β,21-Dihydroxyprogesteron, 4-Pregnen-11β,21-diol-3,20-dion, Kendall’s Compound B, Reichstein’s Substance H
• Empirische Formel (Hill-System): C₂₁H₃₀O₄
• CAS-Nummer: 50-22-6
• Molekulargewicht: 346.46
• Beilstein: 2339601
• EG-Nummer: 200-019-6
• MDL-Nummer: MFCD00037715
• UNSPSC-Code: 12352211
• PubChem Substanz-ID: 57648276
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Assay: ≥98.5% (HPLC)
• Form: powder or crystals
• Optische Aktivität: [α]20/D +223±3°, c = 1% in ethanol
• mp (Schmelzpunkt): 179-183 °C (lit.); 179-183 °C
• Funktionelle Gruppe: ketone
• SMILES String: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChIKey: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Angaben zum Gen: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Beschreibung

Allgemeine Beschreibung

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Anwendung

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Biochem./physiol. Wirkung

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Angaben zur Herstellung

Corticosterone is soluble in chloroform and ethanol.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves