R5653

Monoclonal Anti-hnRNP-Q antibody produced in mouse

clone 18E4, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-Heterogeneous Nuclear Ribonucleoprotein-Q
• MDL-Nummer: MFCD03845440
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 18E4, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 55-70 kDa
• Speziesreaktivität: mouse, bovine, human, rat, canine, Xenopus, chicken
• Methode(n): immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; microarray: suitable; western blot: 1-2 μg/mL using HeLa total cell extract
• Isotyp: IgG1
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SYNCRIP(10492)

Beschreibung

Allgemeine Beschreibung

Monoclonal Anti-hnRNP-Q (mouse IgG1) is derived from the 18E4 hybridoma produced by the fusion of murine myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with recombinant human hnRNP-Q. Heterogeneous nuclear ribonucleoproteins-Q (hnRNP-Q) family of proteins consist of three proteins (Q1, 2, and 3) that are derived by alternative splicing from the same gene.

Spezifität

The hnRNP-Q and hnRNP-R antibodies share 83% homology.

Immunogen

recombinant human hnRNP-Q.

Anwendung

Monoclonal Anti-hnRNP-Q antibody produced in mouse has been used in immunoblotting and immunofluorescence. It may be used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation and immunohistochemistry.

Biochem./physiol. Wirkung

Heterogeneous nuclear ribonucleoproteins (hnRNPs) act in several biological activities such as transcription, pre- mRNA processing, cytoplasmic mRNA translation and turnover. These proteins interact with the survival of motor neurons protein (SMN) that is mutated in patients with spinal muscular atrophy (SMA). Immunodepletion of hnRNP-Q proteins and their localization in spliceosomes, indicate their important role in splicing.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable