Direkt zum Inhalt
Merck

F3922

Sigma-Aldrich

Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-FGFR-3

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

MDL-Nummer:
UNSPSC-Code:
51111800
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~120 kDa

Speziesreaktivität

human

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections
western blot: 1:500 using extract of FGFR-3 transfected cells

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... FGFR3(2261)

Allgemeine Beschreibung

FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.

Immunogen

synthetic peptide corresponding to amino acids 359-372 of the extracellular region of human fibroblast growth factor receptor-3.

Anwendung

Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:
  • immunoblotting
  • immunohistochemistry
  • immunoprecipitation

Biochem./physiol. Wirkung

Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Angaben zur Herstellung

Affinity isolated on a peptide-agarose column.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

F R Lamont et al.
British journal of cancer, 104(1), 75-82 (2010-12-02)
Activating mutations of FGFR3 are frequently identified in superficial urothelial carcinoma (UC) and increased expression of FGFR1 and FGFR3 are common in both superficial and invasive UC. The effects of inhibition of receptor activity by three small molecule inhibitors (PD173074
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo
Lamont FR, et al.
British Journal of Cancer, 104(1), 75-82 (2010)
Fibroblast growth factors: biology, function, and application for tissue regeneration
Yun YR, et al.
Journal of Tissue Engineering, 1(1), 218142-218142 (2010)
Exploring the developmental mechanisms underlying Wolf-Hirschhorn Syndrome: Evidence for defects in neural crest cell migration
Rutherford EL and Lowery LA
Developmental Biology, 420(1), 1-10 (2016)
Loss of heterozygosity at 4p16. 3 and mutation of FGFR3 in transitional cell carcinoma
Sibley K, et al.
Oncogene, 20(6), 686-686 (2001)

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.