R3405

RP-107

≥98% (HPLC), solid

• Synonym(e): 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• Empirische Formel (Hill-System): C₁₆H₁₇N₃O
• CAS-Nummer: 496864-15-4
• Molekulargewicht: 267.33
• MDL-Nummer: MFCD04973541
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824024

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Löslichkeit: DMSO: >10 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• InChIKey: PRIGRJPRGZCFAS-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Leistungsmerkmale und Vorteile

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves