C2992

CFTR Inhibitor-172

≥98% (HPLC), powder, CFTR inhibitor

• Synonym(e): 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
• Empirische Formel (Hill-System): C₁₈H₁₀F₃NO₃S₂
• CAS-Nummer: 307510-92-5
• Molekulargewicht: 409.40
• MDL-Nummer: MFCD06411408
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724436
• NACRES: NA.77

Eigenschaften

• product name: CFTR(inh)-172, ≥98% (HPLC), powder
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: DMSO: ≥10 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
• InChI: 1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+
• InChIKey: JIMHYXZZCWVCMI-RIYZIHGNSA-N

Beschreibung

Anwendung

CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity. It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.

Biochem./physiol. Wirkung

CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a K_i = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves