Q2763

Chinalizarin

≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor

• Synonym(e): 1,2,5,8-Tetrahydroxy-anthrachinon
• Empirische Formel (Hill-System): C₁₄H₈O₆
• CAS-Nummer: 81-61-8
• Molekulargewicht: 272.21
• Farbindexnummer: 58500
• Beilstein: 1889617
• EG-Nummer: 201-366-6
• MDL-Nummer: MFCD00001205
• UNSPSC-Code: 12171500
• PubChem Substanz-ID: 329823863
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Chinalizarin, ≥95% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: red
• mp (Schmelzpunkt): ≥300 °C
• Lagertemp.: room temp
• SMILES String: Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
• InChI: 1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
• InChIKey: VBHKTXLEJZIDJF-UHFFFAOYSA-N

Beschreibung

Anwendung

Quinalizarin has been used:

• as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
• as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
• to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines

Biochem./physiol. Wirkung

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H410
• P-Sätze: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable