PZ0036

Rucaparib camsylate

≥98% (HPLC)

• Synonym(e): 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one camsylate
• Empirische Formel (Hill-System): C₁₉H₁₈FN₃O · C₁₀H₁₆O₄S
• CAS-Nummer: 1859053-21-6
• Molekulargewicht: 555.66
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: pale yellow
• Löslichkeit: DMSO: 2 mg/mL, clear
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: FC1=CC(C(NCC2)=O)=C3C2=C(C4=CC=C(CNC)C=C4)NC3=C1.CC5(C)[C@@H]6CC[C@@]5(CS(O)(=O)=O)C(C6)=O

Beschreibung

Biochem./physiol. Wirkung

Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• H-Sätze: H361
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable