P8765

Ammonium-pyrrolidindithiocarbamat

~99%

• Synonym(e): APDC, Ammoniumtetramethylendithiocarbamat, PDC, PDTC, Pyrrolidin-1-dithiocarbonsäure Ammoniumsalz
• Lineare Formel: C₅H₉NS₂ · NH₃
• CAS-Nummer: 5108-96-3
• Molekulargewicht: 164.29
• Beilstein: 3730472
• EG-Nummer: 225-834-4
• MDL-Nummer: MFCD00012720
• UNSPSC-Code: 12352107
• PubChem Substanz-ID: 24278658
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: microbial
• Qualitätsniveau: 200
• Assay: ~99%
• Form: (powderor powder with lumps)
• mp (Schmelzpunkt): 153-155 °C (lit.)
• Löslichkeit: water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• Lagertemp.: 2-8°C
• SMILES String: N.SC(=S)N1CCCC1
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• InChIKey: MDDIUTVUBYEEEM-UHFFFAOYSA-N
• Angaben zum Gen: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) , RELA(5970)

Beschreibung

Allgemeine Beschreibung

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Anwendung

Ammonium pyrrolidinedithiocarbamate has been used:

• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Biochem./physiol. Wirkung

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves