P5248

Etidronate disodium hydrate

≥97% (NMR), solid

• Synonym(e): Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
• Empirische Formel (Hill-System): C₂H₆Na₂O₇P₂ · xH₂O
• CAS-Nummer: 7414-83-7
• Molekulargewicht: 249.99 (anhydrous basis)
• EG-Nummer: 231-025-7
• MDL-Nummer: MFCD00152567
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329820220
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (NMR)
• Form: solid
• Farbe: white
• mp (Schmelzpunkt): >300 °C
• Löslichkeit: H₂O: ≥10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
• InChI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChIKey: GWBBVOVXJZATQQ-UHFFFAOYSA-L

Beschreibung

Anwendung

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Biochem./physiol. Wirkung

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves