P0778

Pindolol

≥98% (TLC), powder

• Synonym(e): 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
• Empirische Formel (Hill-System): C₁₄H₂₀N₂O₂
• CAS-Nummer: 13523-86-9
• Molekulargewicht: 248.32
• EG-Nummer: 236-867-9
• MDL-Nummer: MFCD00010530
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277795
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Farbe: white to off-white
• mp (Schmelzpunkt): 167-171 °C (lit.)
• Löslichkeit: 0.1 M NaOH: 0.2 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL; 0.1 M HCl: 20 mg/mL; acetic acid: 50 mg/mL; H₂O: insoluble
• Ersteller: Novartis
• Lagertemp.: 2-8°C
• SMILES String: CC(C)NCC(O)COc1cccc2[nH]ccc12
• InChI: 1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
• InChIKey: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADRB1(153) , ADRB2(154) , HTR1A(3350)

Beschreibung

Anwendung

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem./physiol. Wirkung

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

Leistungsmerkmale und Vorteile

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves