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Wichtige Dokumente
S8260
Salbutamol
≥96% (GC), powder, β2 adrenoceptor agonist
Synonym(e):
α-[(tert.-Butylamino)-methyl]-4-hydroxy-m-xylol-α,α′-diol, Albuterol
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About This Item
Empirische Formel (Hill-System):
C13H21NO3
CAS-Nummer:
Molekulargewicht:
239.31
Beilstein:
6405698
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
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Produktbezeichnung
Salbutamol,
Qualitätsniveau
Löslichkeit
methanol: complete 50 mg/ml, clear, colorless to yellow
Ersteller
GlaxoSmithKline
SMILES String
CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
InChI
1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
InChIKey
NDAUXUAQIAJITI-UHFFFAOYSA-N
Angaben zum Gen
human ... ADRB2(154)
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Anwendung
Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.20 Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.21
Biochem./physiol. Wirkung
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
β2-Adrenoceptor Agonist
Leistungsmerkmale und Vorteile
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Anwendung
Produkt-Nr.
Beschreibung
Preisangaben
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1B
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Huib A M Kerstjens et al.
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In patients with severe asthma, tiotropium improves lung function and exacerbation risk when added to high-dose inhaled corticosteroids plus long-acting β2 agonists. We aimed to assess the safety and efficacy of tiotropium in patients with moderate asthma who were symptomatic
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Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous disorders encompassing different phenotypes of airflow obstruction, which might differ in their response to treatment. The aim of this study was to determine distinct phenotypes comprising the syndromes of asthma and
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Combinations of inhaled long-acting bronchodilator therapies such as muscarinic antagonists and β2-agonists may be more effective than monotherapy in the treatment of chronic obstructive pulmonary disease (COPD). This study was a 24-week, Phase III, multicenter, randomized, blinded, double-dummy, parallel-group study
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