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O9637

Sigma-Aldrich

Oxaprozin

solid

Synonym(e):

4,5-Diphenyl-2-oxazolpropansäure

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About This Item

Empirische Formel (Hill-System):
C18H15NO3
CAS-Nummer:
21256-18-8
Molekulargewicht:
293.32
EG-Nummer:
244-296-1
MDL-Nummer:
MFCD00215977
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278617
NACRES:
NA.77

Form

solid

Qualitätsniveau

200

SMILES String

OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3

InChI

1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)

InChIKey

OFPXSFXSNFPTHF-UHFFFAOYSA-N

Angaben zum Gen

human ... PTGIR(5739) , PTGS1(5742) , PTGS2(5743)

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Allgemeine Beschreibung

Oxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA). Oxaprozin binds to albumin. It inhibits arachidonic acid pathway. Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.

Anwendung

Anti-inflammatory

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number
101K1304

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Seda G Sagdinc et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75(4), 1370-1376 (2010-02-20)
The molecular structure, linear and nonlinear optical properties, and electronic properties of 4,5-diphenyl-2-2 oxazole propionic acid (oxaprozin) as a monomer were investigated by using Hartree-Fock (HF) and density functional theory (DFT) calculations that used 6-31G(d,p) basis set. The first-order hyperpolarizability
N Bellamy et al.
Current medical research and opinion, 15(2), 121-127 (1999-09-24)
Although progress has been made in the clinical metrology of pain in rheumatoid arthritis, much further work remains. The preferred methods of measurement remain debatable. In this longitudinal, open study, a comparison of eight self-rating pain scales has been conducted.
Barbara Heller et al.
Current medical research and opinion, 20(8), 1279-1290 (2004-08-25)
To evaluate the efficacy and safety of oxaprozin in comparison with diclofenac in patients with periarthritis pain of the shoulder previously unsuccessfully treated with nonsteroidal anti-inflammatory drugs other than diclofenac and oxaprozin. In this open, multicentre, randomised, controlled study, eligible
K V Reddy et al.
Journal of pharmaceutical and biomedical analysis, 22(4), 651-659 (2000-04-18)
A reversed phase linear gradient liquid chromatographic method was developed for the separation and quantitative determination of the seven known process related impurities and one degraded product of oxaprozin in the bulk drug material. An Inertsil-ODS 3V (150 x 4.6
Bojan D J Božić et al.
Chemical & pharmaceutical bulletin, 60(7), 865-869 (2012-07-14)
A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized. The drug and complexes have been characterized by elemental and thermogravimetric (TG) analysis, Fourier transform (FT)-IR, 1H-NMR, 13C-NMR, UV-Vis
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