M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• Synonym(e): 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• Empirische Formel (Hill-System): C₂₀H₂₂N₄O
• CAS-Nummer: 916923-10-9
• Molekulargewicht: 334.41
• MDL-Nummer: MFCD11045297
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818044
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: oil
• Farbe: pale yellow
• Löslichkeit: DMSO: >5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
• InChIKey: VREPWWBWXVLSEF-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)