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Merck

M149

Sigma-Aldrich

Methiothepin mesylate salt

≥98% (HPLC), solid

Synonym(e):

1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt

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About This Item

Lineare Formel:
C20H24N2S2 · CH3SO3H
CAS-Nummer:
Molekulargewicht:
452.65
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated

Farbe

white

Löslichkeit

H2O: 13 mg/mL

SMILES String

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChIKey

CZMDZGZYKOGLJY-UHFFFAOYSA-N

Allgemeine Beschreibung

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

Anwendung

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

Biochem./physiol. Wirkung

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
C Grånäs et al.
European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies
Primary neuronal precursors in adult crayfish brain: replenishment from a non-neuronal source
Benton J L, et al.
BMC Neuroscience, 12(1), 53-53 (2011)
T Nilsson et al.
European journal of pharmacology, 372(1), 49-56 (1999-06-22)
5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes responsible
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)

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