M0639

6α-Methylprednisolon

≥98%

• Synonym(e): 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadien-3,20-dion, 6α-Methyl-11β,17a,21-trihydroxy-1,4-pregnadien-3,20-dion, Medrol, Medron
• Empirische Formel (Hill-System): C₂₂H₃₀O₅
• CAS-Nummer: 83-43-2
• Molekulargewicht: 374.47
• Beilstein: 2340300
• EG-Nummer: 201-476-4
• MDL-Nummer: MFCD00010591
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24896564
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Sterilität: non-sterile
• Assay: ≥98%
• Form: powder
• Löslichkeit: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• Anwendung(en): cell analysis
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
• InChIKey: VHRSUDSXCMQTMA-PJHHCJLFSA-N
• Angaben zum Gen: human ... NR3C1(2908) ; rat ... Nr3c1(24413)

Beschreibung

Anwendung

6α-Methylprednisolone has been used:

• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
• to induce depletion of CD14⁺ CD16⁺ monocytes
• to study its effect on behavioral and sensory afferent hypersensitivity

Biochem./physiol. Wirkung

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360FD,H373
• P-Sätze: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B - STOT RE 2
• Zielorgane: Adrenal gland,Immune system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)