L9664

Loratadin

≥98% (HPLC), powder

• Synonym(e): 4-(8-Chlor-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yliden-1-piperidincarbonsäure-ethylester
• Empirische Formel (Hill-System): C₂₂H₂₃N₂O₂Cl
• CAS-Nummer: 79794-75-5
• Molekulargewicht: 382.88
• MDL-Nummer: MFCD00672869
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278525
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: soluble 50 mg/mL; H₂O: insoluble
• Ersteller: Schering Plough
• Lagertemp.: 2-8°C
• SMILES String: CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
• InChI: 1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
• InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP3A4(1576) , HRH1(3269) , KCNH1(3756) , KCNH2(3757) , PTAFR(5724) ; rat ... Hrh1(24448)

Beschreibung

Biochem./physiol. Wirkung

Nichtsedierender Histamin H₁-Rezeptorantagonist.

Loratadine is a non-sedating histamine H1-receptor antagonist. Shown to inhibit the two-pore domain potassium channel K2P18.1 (also called TRESK or KCNK18).

Leistungsmerkmale und Vorteile

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)