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L0879

Sigma-Aldrich

Leu-Leu-Leu

≥90% (elemental analysis), suitable for mass spectrometry (MS)

Synonym(e):

Trileucine

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About This Item

Empirische Formel (Hill-System):
C18H35N3O4
CAS-Nummer:
10329-75-6
Molekulargewicht:
357.49
MDL-Nummer:
MFCD00038309
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24896267
NACRES:
NA.26

product name

Leu-Leu-Leu, ≥90% (elemental analysis)

Qualitätsniveau

200

Assay

≥90% (elemental analysis)

Form

powder

Methode(n)

electron microscopy: suitable
mass spectrometry (MS): suitable

Farbe

white

Lagertemp.

−20°C

SMILES String

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

InChIKey

DNDWZFHLZVYOGF-UHFFFAOYSA-N

Verwandte Kategorien

Amino Acid Sequence

Leu-Leu-Leu

Anwendung

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Hui Ding et al.
Biomaterials, 34(1), 217-225 (2012-10-16)
Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as
Hui Ding et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18143-18148 (2010-10-06)
Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cells with drug release into
Anna Andrzejewska et al.
Journal of chromatography. A, 1216(18), 3992-4004 (2009-03-31)
The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorption on a C(12) packing material from an aqueous solution of
Rameshwar Patil et al.
Pharmaceutical research, 27(11), 2317-2329 (2010-04-14)
Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited by severe side effects. Targeted delivery is thus
Tsutomu Kabashima et al.
Peptides, 29(3), 356-363 (2008-01-09)
A novel and selective fluorescence reaction is proposed for the quantitative determination of peptides by reversed-phase liquid chromatography (RPLC). A single fluorescent product was formed when a peptide was heated at 120 degrees C for 20 min in a neutral
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