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K2643

Sigma-Aldrich

KDR (789-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

FLK1, VEGFR, VEGFR2

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.32

Rekombinant

expressed in baculovirus infected Sf9 cells

Qualitätsniveau

200

Produktlinie

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Spezifische Aktivität

53-71 nmol/min·mg

Mol-Gew.

~110 kDa

UniProt-Hinterlegungsnummer

P35968

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... KDR(3791)

Biochem./physiol. Wirkung

KDR (kinase insert domain receptor) is a transmembrane tyrosine kinase receptor which interacts with VEGF (vascular endothelial growth factor) and helps in mediating VEGF downstream angiogenic effects. Blocking KDR suppresses tumor growth and abrogates tumor cell invasion.

Physikalische Form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Rechtliche Hinweise

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Z Zhu et al.
Investigational new drugs, 17(3), 195-212 (2000-02-09)
Angiogenesis, the formation of new blood vessels, is essential for both tumor growth and metastasis. Recent advances in our understanding of the molecular mechanisms underlying the angiogenesis process and its regulation have led to the discovery of a variety of
Baohui Qi et al.
Archiv der Pharmazie, 346(8), 596-609 (2013-07-12)
Novel quinoline derivatives bearing acyclic semicarbazones were prepared and their chemical structures as well as the relative stereochemistry were confirmed. All the synthesized compounds were evaluated for their c-Met kinase inhibitory activity and their cytotoxicity against the cell lines HT-29
G Neufeld et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13(1), 9-22 (1999-01-05)
Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a single VEGF gene. These isoforms differ in their molecular mass and in biological
Chao Sun et al.
Scientific reports, 5, 9774-9774 (2015-05-30)
CHIP (c-terminal Hsp70-interacting protein) is an E3 ligase which may play different roles in different cancers. The elucidation of the VHL-HIF-1α (hypoxia inducible factor-1α)-VEGF (vascular endothelial growth factor) pathway has led to the development of targeted therapy in renal cell

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