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I6410

Sigma-Aldrich

ISCK03

≥98% (HPLC), solid

Synonym(e):

Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl], [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

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About This Item

Empirische Formel (Hill-System):
C19H21N3O2S
CAS-Nummer:
945526-43-2
Molekulargewicht:
355.45
MDL-Nummer:
MFCD12031591
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329815393
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Farbe

yellow

Löslichkeit

DMSO: ≥20 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3

InChI

1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3

InChIKey

XQABBHBFHWHMKF-UHFFFAOYSA-N

Biochem./physiol. Wirkung

ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner.
ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner. ISCK03 inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells. Complete inhibition was observed with 1 and 5 μM ISCK03.

Leistungsmerkmale und Vorteile

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number
098K4624V
098K4624

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Die Dokumentenbibliothek aufrufen

Hiroko Morimoto et al.
PloS one, 4(11), e7909-e7909 (2009-11-26)
Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization and prospective isolation in a deterministic manner; however, our in
Yuan Ma et al.
Cell cycle (Georgetown, Tex.), 19(16), 2074-2080 (2020-07-14)
Neurogenic bladder (NB) is a type of double renal dysfunction caused by nerve lesions. The interstitial cells of Cajal (ICC) damage are involved in bladder dysfunction. The aim of this study is to investigate the effect of stem cell factor
Jin Man Kim et al.
Development (Cambridge, England), 148(6) (2021-03-05)
The actomyosin complex plays crucial roles in various life processes by balancing the forces generated by cellular components. In addition to its physical function, the actomyosin complex participates in mechanotransduction. However, the exact role of actomyosin contractility in force transmission
Keai Sinn Tan et al.
Biology open, 4(5), 596-607 (2015-04-19)
Fetal spleen is a major hematopoietic site prior to initiation of bone marrow hematopoiesis. Morphologic analysis suggested erythropoietic activity in fetal spleen, but it remained unclear how erythropoiesis was regulated. To address this question, we performed flow cytometric analysis and

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