I5521

Monoclonal Anti-Interferon-γ antibody produced in mouse

clone 25718, purified immunoglobulin, lyophilized powder

• Synonym(e): Anti-IFN-γ
• MDL-Nummer: MFCD00162308
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 25718, monoclonal
• Form: lyophilized powder
• Speziesreaktivität: human
• Methode(n): immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood mononuclear cells stimulated with PMA and ionomycin; neutralization: suitable
• Verunreinigungen: endotoxin, tested
• Isotyp: IgG2a
• UniProt-Hinterlegungsnummer: P01579
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IFNG(3458)

Beschreibung

Immunogen

recombinant human interferon-γ, expressed and purified from Escherichia coli.

Biochem./physiol. Wirkung

Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2. There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5. IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Angaben zur Herstellung

Purified using protein A affinity chromatography.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)