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I5403
Insulin-Like Growth Factor Binding Protein-2 human
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
Synonym(e):
IGFBP-2
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About This Item
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in NSO cells
Assay
≥95% (SDS-PAGE)
Form
lyophilized powder
Wirksamkeit
0.04 μg/mL
Mol-Gew.
~36 kDa by SDS-PAGE
calculated mol wt ~31 kDa
Verpackung
pkg of 25 μg
Lagerbedingungen
avoid repeated freeze/thaw cycles
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
endotoxin, tested
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... IGFBP2(3485)
Allgemeine Beschreibung
The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.
Biochem./physiol. Wirkung
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA
Hinweis zur Analyse
The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Inhalation - Eye Irrit. 2
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Soo Hyun Park et al.
Investigative ophthalmology & visual science, 56(12), 7293-7302 (2015-11-13)
Previously, we reported that keratocyte-conditioned medium (KCM) facilitates the differentiation of human mesenchymal stem cells (hMSCs) into corneal keratocyte-like cells. This study is designed to investigate the roles of insulin-like growth factor binding protein 2 (IGFBP2) for the regulation of
Chad P Garner et al.
Human genetics, 123(3), 247-255 (2008-01-23)
The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher
H Yu et al.
Journal of clinical laboratory analysis, 13(4), 166-172 (1999-07-22)
Insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. Clinical and epidemiological studies have indicated that measuring IGFs and IGFBPs in blood has potential implications in assessing growth-related abnormalities and risks
K M Kelley et al.
The international journal of biochemistry & cell biology, 28(6), 619-637 (1996-06-01)
The IGFBPs are a family of homologous proteins that have co-evolved with the IGFs and that confer upon the IGF regulatory system both functional and tissue specificity. IGFBPs are not merely carrier proteins for IGFs, but hold a central position
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