I2526

Insulin-like Growth Factor-II human

IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonym(e): IGF-II
• MDL-Nummer: MFCD00241895
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Assay: ≥98% (SDS-PAGE and HPLC)
• Form: lyophilized powder
• Wirksamkeit: ≤2.0 ng/mL ED₅₀
• Qualität: endotoxin tested
• Mol-Gew.: 7.5 kDa
• Verpackung: pkg of 5X50 μg; pkg of 50 μg
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: ≤0.1 EU/μg
• UniProt-Hinterlegungsnummer: P01344
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IGF2(3481)

Beschreibung

Biochem./physiol. Wirkung

Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution with no additives.

Hinweis zur Analyse

The biological activity is measured by a cell proliferation assay using mouse FDC-P1

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)