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I1786

Sigma-Aldrich

ID-8

≥98% (HPLC)

Synonym(e):

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

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About This Item

Empirische Formel (Hill-System):
C16H14N2O4
CAS-Nummer:
147591-46-6
Molekulargewicht:
298.29
MDL-Nummer:
MFCD00593367
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329815358
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

yellow

Löslichkeit

DMSO: ≥10 mg/mL

Lagertemp.

2-8°C

SMILES String

COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23

InChI

1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3

InChIKey

VVZNWYXIOADGSW-UHFFFAOYSA-N

Allgemeine Beschreibung

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

Biochem./physiol. Wirkung

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

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Stefan Hindel et al.
PloS one, 10(6), e0128060-e0128060 (2015-06-11)
The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven
Yusuke Higuchi et al.
Current molecular pharmacology, 9(3), 272-279 (2015-05-27)
Despite their high degree of identity and even higher homology, the two Kat3 transcriptional coactivators, CBP and p300, have distinct functions, particularly within the Wnt/β-catenin signaling cascade. ICG-001, by directly binding to CBP but not p300, inhibits CBP/β-catenin transcription and
A High-Throughput Screen Identifies DYRK1A inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation
Monteiro M B, et al.
Journal of the American Society of Nephrology, ASN-2018040392 (2018)
Jin Zhou et al.
Annals of translational medicine, 8(20), 1295-1295 (2020-11-20)
In Chinese herbal medicine, Tanshinone IIA (Tan-IIA) is one of the main compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to inhibit the growth of various tumors. However, the detailed molecular and cellular mechanisms of the antitumor effect
Amy A Lo et al.
Molecular cancer therapeutics, 20(4), 716-725 (2021-02-05)
Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as a novel target for therapeutic antibodies for

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