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Merck

H8791

Sigma-Aldrich

Transforming Growth Factor-β3 human

HumanKine®, 95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Synonym(e):

TGF-β3

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352202
NACRES:
NA.77

product name

Transforming Growth Factor-β3 human, TGF-β3, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Biologische Quelle

human

Qualitätsniveau

Rekombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

≤1.0 ng/mL EC50

Qualität

endotoxin tested

Mol-Gew.

dimer 25 kDa (non-glycosylated)

Verpackung

pkg of 5 μg

Hersteller/Markenname

HumanZyme

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

≤1 EU/μg

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

Angaben zum Gen

human ... TGFB3(7043)

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Allgemeine Beschreibung

TGF-β3 (transforming growth factor-β3) belongs to the TGF β superfamily. The TGFβ3 gene is mapped to human chromosome 14q24.3

Biochem./physiol. Wirkung

TGF-β3 (transforming growth factor-β3) regulates lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis to maintain immune homeostasis. TGF-β plays an important role in cell growth, differentiation, and survival. TGF-β3 specifically promotes chondrogenic differentiation.TGF-β3 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils. TGF-β3 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β isoforms is known to participate in wound healing and tissue fibrosis. TGF-β3 is crucial for tissue restoration and scarless tissue repair. Mutation in the TGFβ3 gene is associated with development of non-syndromic cleft palate only (NS CPO), a rare congenital disease.
TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution of 50 mM NaOAc pH 4.5

Angaben zur Herstellung

HumanKine TGF-β3 is expressed in human HEK 293 cells as a mature, disulfide linked, non- glycosylated homodimer with a predicted molecular mass of 25 kDa.
This product is lyophilized from a solution of 50mM NaOAc, pH 3.7.

Hinweis zur Analyse

The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).

Rechtliche Hinweise

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Transforming growth factor β (TGF-β) and inflammation in cancer
Bierie B, et al.
Cytokine & Growth Factor Reviews, 21(1), 49?59-49?59 (2010)
TGFβ3 / SfaN1 gene variant and the risk factor of nonsyndromic cleft palate only among Indonesian patients.
Nasroen SL, et al.
Cellular and Molecular Biology, 63(2), 88-91 (2017)
Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells.
Chen WC, et al.
Journal of Agricultural and Food Chemistry, 61(48), 11817-11824 (2013)
Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway.
Alves MJ, et al.
BMC Cancer, 17(1) (2017)
Linlin Su et al.
Experimental cell research, 316(17), 2945-2960 (2010-08-05)
The intricate interaction between protein endocytosis, transcytosis, recycling and endosome- or ubiquitin-mediated protein degradation determines the junction integrity in epithelial cells including Sertoli cells at the blood-testis barrier (BTB). Studies have shown that androgens and cytokines (e.g., TGF-β3) that are

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