H2539

Anti-HAP40 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Huntingtin-associated Protein 40kDa
• MDL-Nummer: MFCD03791872
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~40 kDa
• Speziesreaktivität: mouse
• Methode(n): western blot: 1:500-1:1,000 using mouse brain
• UniProt-Hinterlegungsnummer: Q00558
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: mouse ... F8A1(14070)

Beschreibung

Allgemeine Beschreibung

Three sequence-identical paralogs of the factor VIII intronic transcript A (F8A) gene codes for huntingtin-associated protein 40 (HAP40) in humans. In amniotes, HAP40 is coded by a single-exon gene (SEG). The F8A or coagulation factor VIII-associated 1 (F8A1) gene is located on human chromosome Xq28.

Immunogen

peptide corresponding to the mouse HAP40 protein (amino acids 314-325).

Anwendung

Co-immunoprecipitates Huntingtin protein.

Biochem./physiol. Wirkung

Huntingtin-associated protein 40 (HAP40) acts as an effector of Ras-related protein 5 (Rab5) It interacts with huntingtin (HTT). HAP40 may participate in the abnormal nuclear localization of mutant huntingtin identified in Huntington′s disease degenerating neurons.

Zielbeschreibung

HAP40 is a 40 kDa Huntingtin-associated protein. It islikely to contribute to the function of normal huntintinand is a candidate for involvement in the aberrantnuclear localization of mutant huntingtin found indegenerating neurons in Huntington′s

Physikalische Form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable