E9750

Estron

≥99% (HPLC), powder, estrogen receptor agonist

• Synonym(e): 1,3,5-Estratrien-3-ol-17-on, 3-Hydroxy-1,3,5(10)-oestratrien-17-on, Folliculin
• Empirische Formel (Hill-System): C₁₈H₂₂O₂
• CAS-Nummer: 53-16-7
• Molekulargewicht: 270.37
• Beilstein: 1915077
• EG-Nummer: 200-164-5
• MDL-Nummer: MFCD00003620
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24278427
• NACRES: NA.77

Eigenschaften

• product name: Estron, ≥99%
• Biologische Quelle: synthetic (organic)
• Sterilität: non-sterile
• Assay: ≥99%
• Form: powder
• mp (Schmelzpunkt): 258-260 °C (lit.)
• Löslichkeit: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
• InChIKey: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• Angaben zum Gen: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , HSD17B1(3292) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Esr1(24890)

Beschreibung

Allgemeine Beschreibung

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Anwendung

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Biochem./physiol. Wirkung

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H351,H360FD,H362
• P-Sätze: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Gefahreneinstufungen: Carc. 2 - Lact. - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges