E6530

Etomidat

>98% (HPLC), powder

• Synonym(e): (R)-1-(α-Methylbenzyl-imidazol-5-carbonsäure-ethylester
• Empirische Formel (Hill-System): C₁₄H₁₆N₂O₂
• CAS-Nummer: 33125-97-2
• Molekulargewicht: 244.29
• EG-Nummer: 251-385-9
• MDL-Nummer: MFCD00869295
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24894630
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: >10 mg/mL
• Ersteller: Johnson & Johnson
• Lagertemp.: 2-8°C
• SMILES String: CCOC(=O)c1cncn1[C@H](C)c2ccccc2
• InChI: 1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
• InChIKey: NPUKDXXFDDZOKR-LLVKDONJSA-N
• Angaben zum Gen: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

Beschreibung

Allgemeine Beschreibung

Etomidate is an imidazole derivative, which functions as an nonbarbiturate hypnotic agent. It is used in speech and memory test. Etomidate regulates hemodynamic stability by preserving sympathetic outflow and autonomic reflexes. It inhibits adrenal steroidogenesis.

Biochem./physiol. Wirkung

Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302 - H410
• P-Sätze: P273 - P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves