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D9760

Sigma-Aldrich

L-(−)-Dithiothreitol

≥95% (titration)

Synonym(e):

(2R,3R)-1,4-Dimercapto-2,3-butandiol, L-DTT, Cleland Reagens chiral

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About This Item

Empirische Formel (Hill-System):
C4H10O2S2
CAS-Nummer:
16096-97-2
Molekulargewicht:
154.25
Beilstein:
2036371
EG-Nummer:
240-263-0
MDL-Nummer:
MFCD00064305
UNSPSC-Code:
12352201
PubChem Substanz-ID:
24894326
NACRES:
NA.25

Qualitätsniveau

100

Assay

≥95% (titration)

Form

powder

Farbe

white

mp (Schmelzpunkt)

49 - 51 °C ((120 - 124 °F))

Löslichkeit

H2O: 50 mg/mL, clear to hazy, colorless

Lagertemp.

−20°C

SMILES String

O[C@@H](CS)[C@@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChIKey

VHJLVAABSRFDPM-IMJSIDKUSA-N

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Anwendung

L-DTT [(2R,3R)-1,4-dimercapto-2,3-butanediol; L-dithiothreitol], a chiral bidentate dithiol with two stereogenic centers, may be used in chiroptical response research. L-DDT is proposed as a stereoselective reducing agent for disulfide bridges in complex molecules.

Sonstige Hinweise

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H412

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 3

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

230.0 °F - closed cup

Flammpunkt (°C)

110 °C - closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Hiroshi Yao et al.
Langmuir : the ACS journal of surfaces and colloids, 29(21), 6444-6451 (2013-05-03)
We here present a study of cross-linking chemistry of optically inactive monothiol-protected gold clusters by chiral bidentate dithiol with two stereogenic centers, (2R,3R)-1,4-dimercapto-2,3-butanediol (L-dithiothreitol; L-DTT), and explore the impacts of the cross-linking on their chiroptical responses. The pristine protective ligand
Stefan Knoppe et al.
Chimia, 67(4), 236-239 (2013-08-24)
Chiral thiolate-protected gold clusters of atomic precision have gained increasing interest in recent years due to their potential use in catalysis, sensing or bioapplications. While the protection of gold clusters with chiral ligands is a rather trivial task, it was
Valérie Robin et al.
Molecular therapy. Nucleic acids, 7, 81-89 (2017-06-19)
Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of motor neurons. In humans, the severity of the disease is
Julia Schueler et al.
Cells, 8(7) (2019-07-22)
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kinase inhibitors, the
Cai Bowen et al.
Cancer research, 79(16), 4124-4134 (2019-06-20)
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