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Wichtige Dokumente
D9150
2,3-Dimethoxy-5-Methyl-p-Benzochinon
apoptosis inducer
Synonym(e):
Coenzym Q0
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Alle Fotos(2)
About This Item
Empirische Formel (Hill-System):
C9H10O4
CAS-Nummer:
Molekulargewicht:
182.17
Beilstein:
1640422
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352204
PubChem Substanz-ID:
NACRES:
NA.51
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Qualitätsniveau
Form
powder
mp (Schmelzpunkt)
58-60 °C (lit.)
Lagertemp.
2-8°C
SMILES String
COC1=C(OC)C(=O)C(C)=CC1=O
InChI
1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
InChIKey
UIXPTCZPFCVOQF-UHFFFAOYSA-N
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Allgemeine Beschreibung
2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0 or DMM) is present in all the cells including neural cells.
Anwendung
2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:
- as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
- as a component in buffer B for cytochrome oxidation assay with subsaturating light
- in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity
Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.
Biochem./physiol. Wirkung
2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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